The following table lists the 15 largest MSAs along the Gulf Coast.
Metropolitan Statistical Areas on the United States Gulf Coast|
| 1 | Houston-Sugar Land-Baytown, TX MSA | 5,867,489 | Houston-Baytown-Huntsville, TX CSA |
| 2 | Tampa-St. Petersburg-Clearwater, FL MSA | 2,747,272 | primary census statistical area |
| 3 | New Orleans-Metairie-Kenner, LA MSA | 1,189,981 | New Orleans-Metairie-Bogalusa, LA CSA |
| 4 | Baton Rouge-Pierre Part, LA CSA | 809,821 | Baton Rouge-Pierre Part, LA CSA |
| 5 | McAllen-Edinburg-Mission, TX MSA | 741,152 | primary census statistical area |
| 6 | North Port-Bradenton-Sarasota, FL MSA | 688,126 | Sarasota-Bradenton-Punta Gorda, FL CSA |
| 7 | Cape Coral-Fort Myers, FL MSA | 586,908 | primary census statistical area |
| 8 | Pensacola-Ferry Pass-Brent, FL MSA | 455,102 | primary census statistical area |
| 9 | Corpus Christi, TX MSA | 416,095 | Corpus Christi-Kingsville, TX CSA |
| 10 | Mobile, AL MSA | 411,721 | Mobile-Daphne-Fairhope, AL CSA |
| 11 | Brownsville–Harlingen, TX MSA | 406,220 | Brownsville-Harlingen-Raymondville, TX CSA |
| 12 | Beaumont-Port Arthur, TX MSA | 378,477 | primary census statistical area |
| 13 | Naples-Marco Island, FL MSA | 318,537 | primary census statistical area |
| 14 | Gulfport-Biloxi, MS MSA | 238,772 | Gulfport-Biloxi-Pascagoula, MS CSA |
| 15 | Houma-Bayou Cane-Thibodaux, LA MSA | 202,973 | primary census statistical area |